September 02, 2010
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| Generalizability of clinical trials for cannabis dependence to community samples - Drug and Alcohol Dependence |
| Okuda M et al. – The results also support the notion that clinical trials tend to recruit highly selective samples, rather than adults who are representative of typical patients. Clinical trials should carefully evaluate the effects of eligibility criteria on the generalizability of their results. Even in efficacy trials, stringent exclusionary criteria could limit the representativeness of study results.... |
| Estimation of Prostate Size in Community-dwelling Men - Urology |
| Jacobson DJ et al. – The study uses two population–based samples of prostate cancer–free men to develop and validate a novel multivariable equation for estimating prostate volume (PV). Previous investigators have demonstrated the ability to use serum prostate–specific antigen (PSA) levels to estimate PV in men without prostate cancer; however, the ability of additional clinical variables to further enhance PV estimation in these men remains unclear. The data suggest that PV can be estimated with easily obtained clinical variables. Moreover, the authors demonstrate that age and weight can be added to PSA level to achieve greater accuracy in predicting PV. This methodology may prove useful for estimating PV in men in settings where costs and practicality preclude the use of imaging techniques.... |
| Community Management of Anti-malarials in Africa and Iatrogenic Risk - Journal of Tropical Pediatrics |
| Orostegui L et al. – A persistent fever suspected to be due to malaria was treated inappropriately with atovaquone–proguanil and then with sulfadoxine–pyrimethamine again. Cumulative toxicity of anti–malarials leads to irreversible hepatic damages requiring hepatic transplantation. Community caretakers must be aware of the potential side effects and the contraindications of anti–malarials. Early identification of drug–induced toxicity and immediate discontinuation of the drug are the more effective tools to limit the progression of tissue damage.... |
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