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February 08, 2010 Assessing the cost-effectiveness of drug and lifestyle intervention following opportunistic screening for pre-diabetes in primary care - Diabetologia - Clinical and Experimental Diabetes and Metabolism Bertram MY et al. – Screening for pre–diabetes followed by diet and exercise, or metformin treatment is cost–effective and should be considered for incorporation into current practice. The number of dietitians and exercise physiologists needed to deliver such lifestyle change interventions will need to be increased to appropriately support the intervention.... 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the progression of renal dysfunction in Japanese hypertensive patients - Geriatrics and Gerontology International Kuwabara M et al. – Lipid–lowering intervention with statins inhibits the progression of CKD in hypertensive patients.... Bezafibrate for the treatment of primary sclerosing cholangitis - Journal of Gastroenterology Hirano K et al. – The study showed that bezafibrate could lower the levels of hepatobiliary enzymes in about half of a cohort of patients with PSC.... Health-related quality of life in patients with metastatic renal cell carcinoma treated with sunitinib vs interferon-alpha in a phase III trial: final results and geographical analysis - British Journal of Cancer Cella D et al. – Patients treated with sunitinib in this study had improved HRQoL, compared with patients treated with IFN–alpha. Treatment differences within the US cohort did not differ from those within the EU cohort.... Pulsed intravenous cyclophosphamide and methylprednisolone therapy in refractory pemphigus - British Journal of Dermatology Saha M et al. – PPC can be an effective treatment for refractory pemphigus but its adverse effects should be considered prior to therapy and closely monitored in patients on treatment.... Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system - BMC Medicine Van Cott AC et al. – The extensive diagnostic and treatment data demonstrated that the strongest predictor of suicide–related behaviors for older patients newly treated with AED monotherapy was a previous diagnosis of affective disorder. Additional, research using a larger sample is needed to clearly determine the risk of suicide–related behaviors among less commonly used AEDs.... A randomized phase II study of carboplatin plus pegylated liposomal doxorubicin versus carboplatin plus paclitaxel in platinum sensitive ovarian cancer patients: a Hellenic Cooperative Oncology Group study - BMC Medicine Bafaloukos D et al. – The combination of pegylated LD with carboplatin is effective, showing less neurotoxicity and alopecia than paclitaxel–carboplatin. It thus warrants a further phase III evaluation as an alternative treatment option for platinum–sensitive OC patients.... Pharmacokinetics of Amantadine in Children With Impaired Consciousness due to Acquired Brain Injury: Preliminary Findings Using a Sparse-sampling Technique - PM&R Vargus–Adams JN et al. – Amantadine was well–tolerated in children with acquired brain injury and demonstrates pharmacokinetics similar to those reported for healthy young adults. Based on the preliminary data, higher dosing may be considered in the setting of brain injury.... Pramipexole combined with levodopa improves motor function but reduces dyskinesia in MPTP-treated common marmosets - Movement Disorders Tayarani–Binazir KA et al. – The results suggest that pramipexole could be administered with a reduced dose of levodopa to minimize dyskinesia in Parkinson's disease while maintaining therapeutic efficacy.... High-risk Diabetic Patients in Medicare Part D Programs: Are They Getting the Recommended ACEI/ARB Therapy? - Journal of General Internal Medicine Yang Y et al. – ACEI/ARB utilization rates were 63%, 58.3%, and 43.1% among diabetic patients with hypertension and renal disease, hypertension without renal disease, and renal involvement without hypertension, respectively. After adjusting for all other characteristics studied, patients in the hypertension only and renal disease only risk groups were less likely to use ACEI/ARB compared to diabetes patients with both hypertension and renal disease. Several demographics, including male gender, age older than 65, and white race, were all predictors of suboptimal ACEI/ARB use. Results from state–specific analyses are consistent with those for all six states. In this cohort, less than 60% of high–risk patients with diabetes were receiving the recommended ACEI/ARB therapy. Several patient demographic and clinical characteristics are strongly associated with suboptimal ACEI/ARB use.... More News...