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February 08, 2010 Use of mirtazapine in an adult with refractory anorexia nervosa and comorbid depression - International Journal of Eating Disorders Darcy AM et al. – A 50–year–old woman with an over 7–year history of AN and comorbid major depression had been treated unsuccessfully with numerous psychotropic medications, manualized cognitive behavior therapy, and an intensive outpatient treatment program before referral. After treatment with mirtazapine, she gained weight and her depression improved. A 9–month follow–up revealed a maintenance of these benefits. Mirtazapine may be useful for older, chronically ill patients presenting with AN and comorbid depression.... Poly-Victimization and Risk of Posttraumatic, Depressive, and Substance Use Disorders and Involvement in Delinquency in a National Sample of Adolescents - Journal of Adolescent Health Ford JD et al. – Poly–victimization is prevalent among adolescents and places youth at high risk for psychiatric impairment and for delinquency. Moreover, poly–victimized youths' risk of delinquency cannot be fully accounted for by posttraumatic stress disorder, depression, or substance use problems, suggesting that adolescent healthcare providers should consider poly–victimization as a risk for behavioral and legal problems even when PTSD, depression, or addiction symptoms are not clinically significant.... Attention-Deficit/Hyperactivity Disorder - Pediatrics in Review Wilms Floet AM et al. – Based on strong research evidence, school–age children who present with behavior problems or academic underachievement should receive an evaluation for ADHD. Based on consensus and strong research evidence, ADHD–specific rating scales may be used to evaluate a child for symptoms of ADHD, but they are not diagnostic of ADHD. Based on strong research evidence, approximately 67% of patients diagnosed as having ADHD have comorbid mood disorder or learning disorder. Based on strong research evidence, the primary care clinician should establish a treatment program that recognizes ADHD as a chronic condition that requires ongoing management and monitoring. Based on strong research evidence, the clinician initially should recommend stimulant medication for the treatment of ADHD, with stimulant drugs from either class (amphetamines, methylphenidate) being equally effective.... Understanding Relations Among Early Family Environment, Cortisol Response, and Child Aggression via a Prevention Experiment - Child Development O'Neal CR et al. – The current study examined whether changes in cortisol response were related to later child aggression. Among lower warmth families, the intervention effect on aggression was largely mediated by the intervention effect on cortisol response. Although the intervention also resulted in significant benefits on child engaging behavior, cortisol response did not mediate this effect. These findings demonstrate meaningful associations between cortisol response and aggression among children at familial risk for antisocial behavior.... Morphological Abnormalities of the Thalamus in Youths With Attention Deficit Hyperactivity Disorder - American Journal of Psychiatry Ivanov I et al. – The findings demonstrate reduced pulvinar volumes in youths with ADHD and indicate that this same area is relatively enlarged in patients treated with stimulants compared to those untreated. Associations of hyperactivity scores with smaller regional volumes on the lateral thalamic surface and inattention scores with larger regional volumes on the medial thalamic surface suggest the differential involvement of thalamic subcircuits in the pathogenesis of differing ADHD symptoms.... The Relation Between Peak Response Magnitudes and Agreement in Diagnoses Obtained From Two Different Phallometric Tests for Pedophilia - Sexual Abuse: A Journal of Research and Treatment Lykins AD et al. – The results showed that examinees with inconsistent diagnoses responded less on both tests and that examinees with inconsistent diagnoses responded less on the second test after controlling for their response on the first test. Results also indicated that at response levels less than 1 cm3, diagnostic consistency was no better than chance, supporting the establishment of a minimum response level criterion.... Nonmedical use of prescription stimulants and depressed mood among college students: Frequency and routes of administration - Journal of Substance Abuse Treatment Teter CJ et al. – Studies demonstrate associations between nonmedical use of prescription stimulants (NMUPS) and depressed mood; however, relevance of NMUPS route of administration and frequency of use have not been examined. Nonmedical users of prescription stimulants should be screened for depressed mood, especially those who report frequent and nonoral routes of administration.... Efficacy of valproate versus lithium in mania or mixed mania: a randomized, open 12-week trial - International Clinical Psychopharmacology Bowden CL et al. – Valproate and lithium showed comparable efficacy and tolerability in the treatment of acute mania over 12 weeks.... Productivity Losses Among Treated Depressed Patients Relative to Healthy Controls - Journal of Occupational and Environmental Medicine Curkendall S et al. – Even when depressed patients are treated with antidepressants, there are substantial productivity losses. Therapies that can better manage depression may provide opportunities for savings to employers.... Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans - Nicotine & Tobacco Research David SP et al. – In 2 different ethnic American populations, authors observed man–woman variation in the influence of the rs2303380–rs4938015–rs11604671 GTG haplotype on smoking initiation and cessation. These results should be replicated in larger cohorts to establish the relationship among the rs2303380–rs4938015–rs11604671 haplotype block, sex, and smoking behavior.... More News...