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September 03, 2010
Osteoporosis in Men - American Family Physician
Rao SS et al. – Osteoporosis is an important and often overlooked problem in men. Although the lifetime risk of hip fracture is lower in men than in women, men are twice as likely to die after a hip fracture. Bone mineral density measurement with a T–score of –2.5 or less indicates osteoporosis. All men diagnosed with osteoporosis should be evaluated for secondary causes of bone loss. Pharmacotherapy is recommended for men with osteoporosis and for high–risk men with low bone mass (osteopenia) with a T–score of –1 to –2.5. Bisphosphonates are the first–line agents for treating osteoporosis in men. Teriparatide (i.e., recombinant human parathyroid hormone) is an option for men with severe osteoporosis. Testosterone therapy is beneficial for men with osteoporosis and hypogonadism. Adequate intake of calcium and vitamin D should be encouraged in all men to maintain bone mass. Men should be educated regarding lifestyle measures, which include weight–bearing exercise, limiting alcohol consumption, and smoking cessation. Fall prevention strategies should be implemented in older men at risk of falls....
Ankle Strength and Functional Limitations in Children and Adolescents With Type I Osteogenesis Imperfecta - Pediatric Physical Therapy
Caudill A et al. – Ankle plantar flexor weakness is present in children and adolescents with type I OI and correlates with function. Gillette Functional Assessment Questionnaire, PODCI, and strength assessment are valuable evaluation tools for children and adolescents with type I OI and can aid therapists in goal setting....
Ankle positioning and knee perturbation affect temporal recruitment of the vasti muscles in people with patellofemoral pain - Physiotherapy
Ng ECT et al. – These findings suggest the potential benefits of unexpected perturbation activities for facilitating VMO activation. The clinical applications of perturbation tasks in rehabilitation exercise programmes and the underlying mechanisms warrant further investigation....
Physical Activity Positively Predicts Bone Architecture and Bone Strength in Adolescent Males and Females - Acta Pediatrica
McKay H et al. – This findings suggest that ImpactPA is significantly associated with bone architecture and bone strength in adolescent males and females....
The Combined Effects of Limited Nutrition and High-Frequency Loading on Intervertebral Discs With Endplates - Spine
Illien–Junger S et al. – Supporting in vivo studies and cell culture experiments, high–frequency loading simulating vibration conditions shows detrimental effects on intervertebral disc cells in whole organ culture. The effect on cell viability was exacerbated by limited nutrition culture. However, neither frequency nor limited glucose affected cell metabolism, measured by glycosaminoglycan synthesis rate. Longer culture periods may be required to detect changes at the extracellular matrix level....
Motion Deficit of the Thumb in CMC Joint Arthritis - The Journal of Hand Surgery
Gehrmann SV et al. – Severe stages of thumb CMC OA cause an asymmetrical motion deficit with decreased ROM in extension and adduction, leading to decreased capability of counteropposition....
Spotlight on Strontium Ranelate+: In Postmenopausal Osteoporosis - Drugs & Aging
Deeks ED et al. – The nature of adverse events was generally similar regardless of treatment duration in clinical trials, with the most commonly reported being nausea and diarrhoea over 5 years of treatment, and memory loss and diarrhoea during longer–term treatment. Although an increased risk of venous thromboembolism was associated with strontium ranelate relative to placebo over 5 years of treatment in a pooled analysis of clinical trials, postmarketing data have not confirmed this finding. Overall, the clinical data available suggest that strontium ranelate is an effective and generally well tolerated option for the first–line treatment of postmenopausal osteoporosis....

September 02, 2010
Elderly-onset rheumatoid arthritis - Joint, Bone, Spine
Soubrier M et al. – Data on the efficacy of TNF–alpha antagonists in therapeutic trials are available only for etanercept. Disease activity decreased and function improved. The adverse event rate was higher in older patients, but this was also true of the conventional drugs used as comparators. Registry data confirm that TNF–alpha antagonist therapy is effective in rheumatoid arthritis. An increased rate of infections was found only in some registries. To combat the 2–fold cardiovascular risk increase associated with rheumatoid arthritis, disease activity should be stringently controlled and all cardiovascular risk factors managed aggressively....

September 01, 2010
Vascular disease is associated with facet joint osteoarthritis - Osteoarthritis and Cartilage
Suri P et al. – Abdominal aortic calcifications were associated with facet joint osteoarthritis in this community–based population, when adjusting for epidemiologic factors associated with spinal degeneration, and cardiovascular risk factors. Potentially modifiable risk factors for facet degeneration unrelated to conventional biomechanical paradigms may exist. This study is limited by cross–sectional design; longitudinal studies are needed....
The effectiveness of interventions in the management of patients with primary frozen shoulder - The Journal of Bone and Joint Surgery (British Volume)
Rookmoneea M et al. – More rigorous randomised trials are needed to evaluate the treatments used for frozen shoulder....

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