September 03, 2010
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| Mucosa-Associated Lymphoma Tissue of the Dura Presenting as Meningioma - Southern Medical Journal |
| Shaia J et al. – The neoplastic small lymphoid B cells were MUM1 positive and showed kappa light chain restriction, consistent with MALT of the dura. No evidence of systemic disease was found. The patient underwent radiation, which resulted in a complete response. MALT lymphoma, while rare, must be considered in the differential diagnosis in patients presenting radiographically with meningioma.... |
| High von Willebrand Factor Levels Increase the Risk of Stroke. The Rotterdam Study - Stroke |
| Wieberdink RG et al. – During an average follow–up time of 5.0 years, 290 first–ever strokes occurred, of which 197 were classified as ischemic. The risk of stroke increased with increasing von Willebrand factor levels (age– and sex–adjusted hazard ratios per SD increase in von Willebrand factor level: 1.12 for stroke, 1.13. Adjustments for additional confounders slightly attenuated the association. The association was also present in subjects without atrial fibrillation and did not differ between sexes. High von Willebrand factor levels are associated with stroke risk in the general population.... |
| Therapeutic Approaches to Multiple Sclerosis: An Update on Failed, Interrupted, or Inconclusive Trials of Neuroprotective and Alternative Treatment Strategies - BioDrugs |
| Meuth SG et al. – Currently approved multiple sclerosis therapeutics have a mainly anti–inflammatory mode of action. However, a number of promising clinical trials have been initiated that either focus on neuroprotection or follow completely different treatment strategies. So far, all of these clinical trials have failed to show efficacy or had to be halted prematurely because of unexpected adverse events. Some others show results that are of unknown significance with regard to a reliable assessment of true efficacy versus safety. Previously failed therapeutic approaches in MS have indicated that there are discrepancies between the theoretical expectations and practical outcomes of different compounds.... |
| Risk of “silent stroke” in patients older than 60 years: risk assessment and clinical perspectives - Clinical Interventions in Aging |
| Lim JS et al. – Over 20% of the elderly exhibit silent brain infarction(SBI), and the prevalence of SBI increases steadily with age, ie, 30%–40% in those older than 70 years. Well–known cardiovascular risk factors such as hypertension has been identified as a risk factor of SBI Besides this, blood pressure (BP) reactivity to mental stress, morning BP surges, and orthostatic BP changes have been demonstrated to contribute to the presence of SBI. Further, a metabolic syndrome not only as a whole syndrome (OR = 2.18) but also as individual components could have an influence on SBI. Increased C–reactive protein and interleukin–6, coronary artery disease, body mass index, and alcohol consumption have also been associated with SBI. The ORs and possible mechanisms have been discussed in this article. Overt stroke, dementia, depression, and aspiration pneumonia were all associated with SBI. (overt stroke: hazard ratio [HR] = 1.9, 95% confidence interval [CI]; 1.2–2.8; dementia: HR = 2.26, 95% CI: 1.09–4.70).... |
| Endovascular Parent Artery Occlusion for the Treatment of Wide-Neck A1 Segment Aneurysms: A Single-Center Experience - American Journal of Neuroradiology |
| Tollard E et al. – The goal of this study was to evaluate the feasibility and efficacy of A1 occlusion at the level of wide necked A1 aneurysms, where there are bilateral patent A1 segments and a patent AcomA. Between 2000 and 2010, 9 patients with wide necked A1 aneurysms were treated by coiling of the aneurysm along with parent vessel occlusion. None of the aneurysms ruptured on follow–up. In this series, parent artery occlusion was effective in treating wide–necked aneurysms arising from the A1 segment in patients with adequate collateral supply.... |
| Cerebrospinal Fluid Flow Dynamics in the Central Nervous System - Annals of Biomedical Engineering |
| Sweetman B et al. – The mathematical model presented in this article is a prerequisite for developing a mechanistic understanding of the relationships among vasculature pulsations, CSF flow, and CSF pressure waves in the CNS.... |
| Magnetization Transfer MR Imaging Demonstrates Degeneration of the Subcortical and Cortical Gray Matter in Huntington Disease - American Journal of Neuroradiology |
| Ginestroni A et al. – GM is typically affected in HD since the presymptomatic stage. The aim was to investigate with MT MR imaging the microstructural changes of the residual brain subcortical and cortical GM in carriers of the HD gene and to preliminarily assess their correlation with the clinical features. MT imaging demonstrates degeneration of the subcortical and cortical GM in HD carriers and might serve, along with volumetric assessment, as a surrogate marker in future clinical trials of HD.... |
| Intraarterial Thrombolysis and Stent Placement for Acute Basilar Artery Occlusion - Journal of Vascular and Interventional Radiology |
| Yu YY et al. – To study retrospectively the prognostic factors for acute basilar artery occlusion treated with intraarterial thrombolysis and stent placement. NIHSS scores less than 14 on admission and successful recanalization can predict favorable outcome for patients with basilar artery occlusion. This study shows that intraarterial thrombolysis and stent placement may be a useful treatment for acute basilar artery occlusion.... |
| Thrombolytic therapy in a patient with acute ischemic stroke caused by aortic dissection - Clinical Neurology and Neurosurgery |
| Noel M et al. – The current medical literature indicates a poor outcome in patients with ischemic stroke in the presence of aortic dissection, especially in those who underwent thrombolytic therapy. The authors report a favorable outcome in a patient with acute stroke who received rt–PA and was later found to have Stanford type A aortic dissection.... |
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