February 08, 2010
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| Cerebral Magnetic Resonance Biomarkers in Neonatal Encephalopathy: A Meta-analysis - Pediatrics |
| Thayyil S et al. – Deep gray matter Lac/NAA is the most accurate quantitative MR biomarker within the neonatal period for prediction of neurodevelopmental outcome after NE. Lac/NAA may be useful in early clinical management decisions and counseling parents and as a surrogate end point in clinical trials that evaluate novel neuroprotective therapies.... |
| Rating scales for dystonia in cerebral palsy: reliability and validity - Developmental Medicine & Child Neurology |
| Monbaliu E et al. – The results support the internal consistency and concurrent validity of the scales; however, taking into consideration the limitations in reliability, including the large SDD values and the content validity, further research on methods of assessment of dystonia is warranted.... |
| Long-term motor cortex stimulation for amyotrophic lateral sclerosis - Brain Stimulation |
| Di Lazzaro V et al. – Although the authors cannot be sure whether the effects observed in the patient treated with rTMS can be attributed to this form of stimulation, this study set the groundwork for possible future studies investigating the effects of rTMS, for a prolonged period, on a larger group of ALS patients.... |
| Muscle MRI in Myotonic Dystrophy Type 1 with Foot Drop - European Neurology |
| Hamano T et al. – The patients presenting with gait disturbance showed high intensity signals in the semimembranosus, vastus intermedius and gastrocnemius medialis muscles, too. Disturbance of the gastrocnemius lateralis muscles was mild in all DM1 patients. The patients without gait disturbance showed no abnormalities, especially in tibialis anterior muscles on muscle MRI. Muscle MRI is useful for the detection of pathological muscles in DM1 patients with gait disturbance.... |
| Sporadic hemiplegic migraine and CREST syndrome - The Journal of Headache and Pain |
| Grecco MP et al. – The authors report the case of a woman with sporadic hemiplegic migraine associated with CREST syndrome (calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Since there is a close relationship between migraine and Raynaud’s phenomenon, it could be speculated that the sporadic hemiplegic migraines in this patient might be secondary to CREST syndrome.... |
| Treatment adherence in multiple sclerosis: association with emotional status, personality, and cognition - Journal of Behavioral Medicine |
| Bruce JM et al. – Results indicated that MS patients with current mood or anxiety disorders were almost five times as likely as MS patients with no psychiatric diagnosis to exhibit problems adhering to their disease modifying therapies. Poor adherence was also associated with memory difficulties, anxiety, depression, neuroticism, and low conscientiousness. Findings highlight the importance of conducting a thorough psychiatric and neuropsychological evaluation when clinicians suspect poor adherence to disease modifying therapies. Pharmacological or psychotherapeutic treatment of mood/anxiety disorders, use of scheduled reminders, and/or increased organization and structure may lead to improved treatment adherence in MS.... |
| Breastfeeding, the use of docosahexaenoic acid-fortified formulas in infancy and neuropsychological function in childhood - BMJ - Archives of Diseases in Childhood |
| Gale CR et al. – In unadjusted analyses, children for whom breast milk or DHA–fortified formula was the main method of feeding throughout the first 6 months of life had higher mean full–scale and verbal IQ scores at age 4 years than those fed mainly unfortified formula. After adjustment for potential confounding factors, particularly maternal IQ and educational attainment, the differences in IQ between children in the breast milk and unfortified formula groups were severely attenuated, but children who were fed DHA–fortified formula had full–scale and verbal IQ scores that were respectively 5.62 (0.98 to 10.2) and 7.02 (1.56 to 12.4) points higher than children fed unfortified formula. However, estimated total intake of DHA in milk up to age 6 months was not associated with subsequent IQ or with score on any other test. Differences in children’s intelligence according to type of milk fed in infancy may be due more to confounding by maternal or family characteristics than to the amount of long–chain polyunsaturated fatty acids they receive in milk.... |
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