February 08, 2010
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| Disinfection by-products in drinking water and colorectal cancer: a meta-analysis - International Journal of Epidemiology |
| Rahman MB et al. – The study findings provide limited evidence of a positive association between colorectal cancer and exposure to disinfection by–products (DBPs) in drinking water. The small number of studies and limitations in study quality prevent causal inference.... |
| Clear cell sarcoma of the kidney in children: experience in a developing country - Pediatric Surgery International |
| Hadley GP et al. – In a developing country, CCSK is rare and clinically and radiologically indistinguishable from Wilms tumour. Associated hypertension is common. Pretreatment diagnosis is difficult and sampling errors using needle biopsies may be unavoidable. Treatment results are poor and, given the propensity for late recurrence in CCSK, may not be sustained.... |
| Grape seed beneficial in fight against cancer and heart disease - The Clinical Advisor |
| Sego S et al. – We are well aware of the constant damage done to our cell structures by oxidative effects from free radicals and other proinflammatory entities. While grape seed is certainly not the only natural compound to exert these protective effects, it is worth considering when consulting with patients about their health. Careful attention should be paid, however, to the significant drug interaction profile of grape seed, and patients should be screened for the use of these medications.... |
| Leukemia, non-Hodgkins lymphoma, and Wilms tumor in childhood: the role of birth weight - European Journal of Pediatrics |
| Rangel M et al. – The present study supports the hypothesis that high birth weight is an independent risk factor for childhood Wilms tumor, leukemia, and non–Hodgkin lymphoma. Further studies should explore biological reasons to explain this relationship and, ultimately, to expand our knowledge about prenatal influences on the occurrence of this disease.... |
| A 40-year-old man with spells of generalized weakness and paresthesias - Cleveland Clinic Journal of Medicine |
| Nguyen DL et al. – The diagnosis of hereditary hemorrhagic telangiectasia (HHT) is based on the following four clinical criteria: spontaneous or recurrent epistaxis, multiple mucocutaneous telangiectases, visceral involvement (eg, cerebral, pulmonary, or gastrointestinal AVM), and a first–degree relative with this disease. The diagnosis may be confirmed with genetic testing. The diagnosis may be underreported, given the wide spectrum of disease presentation, from inconsequential epistaxis to massive gastrointestinal bleeding. HHT is autosomal dominant, and therefore all first–degree relatives should be screened.... |
| Is Computed Tomographic Colonography Being Held to a Higher Standard? - Annals of Internal Medicine |
| Garg S – Recent guidelines for colorectal cancer screening have reached different conclusions on whether computed tomographic colonography (CTC) is an acceptable screening option, and the Centers for Medicare & Medicaid Services recently decided not to cover CTC screening. The rationale against recommending or covering CTC screening includes concerns about radiation exposure, false–negative rates for small polyps, the discovery of extracolonic findings, variability in performance, a lack of targeted studies, a higher adenoma rate in the Medicare–eligible age group, and an absence of evidence that covering CTC would increase overall screening rates. Similar concerns can be raised for other recommended and covered colon cancer screening tests, but it seems that CTC is being held to a new and higher standard.... |
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