September 03, 2010
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| Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression - International Journal of Cancer |
| Sprenger CC et al. – Age is the greatest risk factor for the development of epithelial cancers. In this minireview, the auuthors will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, the authors will use prostate cancer as the model throughout this minireview.... |
| The challenge of targeting EGFR: experience with gefitinib in nonsmall cell lung cancer - European Respiratory Review |
| Armour AA et al. – IPASS showed that EGFR mutation was the strongest predictor of improved progression–free survival (mutation–positive subgroup hazard ratio (HR) 0.48, 95% CI 0.36–0.64; mutation–negative subgroup HR 2.85, 95% CI 2.05–3.98 with gefitinib versus carboplatin/paclitaxel as first–line therapy for advanced NSCLC. Important lessons for the development of future personalised medicines are discussed.... |
| Seeking Patient Feedback: An Important Dimension of Quality in Cancer Care - Journal of Nursing Care Quality |
| Richard ML et al. – A patient satisfaction survey was conducted with ambulatory cancer patients to identify areas that they consider priorities for change. Wait times and telephone contact with healthcare providers were the 2 areas of lowest satisfaction. Despite previous interventions to improve wait times, it is consistently the lowest ranked item for patient satisfaction. ... |
| Practical Approaches to Pharmacologic Management of Pain in Older Adults With Cancer - Oncology Nursing Forum |
| Brant JM et al. – Unrelieved pain can have a detrimental effect on older adults; conversely, overmedicating can lead to an increased risk of adverse events. With advancing age, physiologic changes alter the pharmacokinetic and pharmacodynamic properties of drugs by reducing their absorption, changing their distribution, and modifying their metabolism and elimination. Also, common comorbidities increase the risk of pharmacologic toxicity and narrow the therapeutic window. In addition, polypharmacy—an issue more common in older adults—increases the complexity of prescribing and risk of adverse events. Consequently, older adults require individualization of their pharmacotherapies. Healthcare providers should consider carefully the risks and benefits of nonsteroidal anti–inflammatory drugs, opioids, and adjuvants before initiating an analgesic trial. ... |
| Outcome Measures to Evaluate the Effectiveness of Pain Management in Older Adults With Cancer - Oncology Nursing Forum |
| Miaskowski C – Particularly in older adults, evaluation of functional outcomes provides a better indication of the effectiveness of pain management strategies than pain intensity ratings. Appropriate outcome measures for older adults in the outpatient setting include pain relief, physical functioning, emotional functioning, patients' ratings of global improvement and satisfaction with treatment, and symptoms and adverse effects associated with analgesic medications.... |
| Management of sialoblastoma with surgery and brachytherapy - Pediatric Blood & Cancer |
| Shan XF et al. – Sialoblastoma is a rare congenital or perinatal salivary gland tumor with significant variability in histological appearance and biological behavior. The authors reported one case of sialoblastoma occurring in the parotid gland of an 18–month–old female. The tumor was excised with negative margins, and the sacrificed facial nerve was reconstructed with great auricular nerve graft. The tumor recurred 6 months after operation and was treated with 125I seed implant brachytherapy.... |
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