September 03, 2010
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| Lack of Increase in Vancomycin Resistance of Pediatric Methicillin-Resistant Staphylococcus aureus Isolates From 2000 to 2007 - The Pediatric Infectious Disease Journal |
| Zheng X et al. – The authors retrospectively studied 306 pediatric methicillin–resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration change over time using Etest, agar dilution, and broth microdilution methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly. Considerably different proportions of isolates with vancomycin MIC = 2 micro g/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data.... |
| HIV protease inhibitors and obesity - Current Opinion in Endocrinology, Diabetes and Obesity |
| Anuurad E et al. – To review the current scientific literature and recent clinical trials on HIV protease inhibitors and their potential role in the pathogenesis of lipodystrophy and metabolic disorders. Protease inhibitors are a key component of antiretroviral therapy and have dramatically improved the life expectancy of HIV–infected individuals. However, they are also associated with abnormalities in glucose/lipid metabolism and body fat distribution. Further studies are needed to better define the pathogenesis of protease inhibitor–associated metabolic and body fat changes and their potential treatment.... |
| Complications of Varicella After Implementation of Routine Childhood Varicella Vaccination in Germany - The Pediatric Infectious Disease Journal |
| Spackova M et al. – A country–wide sentinel surveillance system was initiated in Germany after implementation of routine varicella vaccination of children >11 months. Sentinel physicians report monthly the number of cases and of severe varicella complications (VC). Case–based questionnaires are completed for VC. The authors evaluated trend and clinical features of reported VC from April 2005 to March 2009. ... |
| Education, survival and avoidable deaths in cancer patients in Finland - British Journal of Cancer |
| Pokhrel A et al. – Relative survival after cancer in Finland is at the highest level observed in Europe and has, in general, been on a steady increase. The study assesses whether the high survival is equally shared by different population subgroups and to estimate the possible gains that might be achieved if equity prevailed.... |
| Antivirals for Influenza: Strategies for Use in Pediatrics - Pediatric Drugs |
| Smith SM et al. – Additional concerns with neuraminidase inhibitor use in pediatrics center around emerging reports, primarily from Japan, that have temporally linked oseltamivir to significant neuropsychiatric events in children of varying ages. Numerous novel antiviral agents are under development, but most are far from market approval. In addition to treating and preventing the initial burden of pediatric influenza infection, antiviral therapies may significantly reduce secondary bacterial infections, unnecessary antibiotic prescribing, and healthcare–associated costs.... |
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