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September 03, 2010
Lack of Increase in Vancomycin Resistance of Pediatric Methicillin-Resistant Staphylococcus aureus Isolates From 2000 to 2007 - The Pediatric Infectious Disease Journal
Zheng X et al. – The authors retrospectively studied 306 pediatric methicillin–resistant Staphylococcus aureus isolates collected in 2000/2001, 2003, 2005, and 2007 for possible vancomycin minimum inhibitory concentration change over time using Etest, agar dilution, and broth microdilution methods. Vancomycin MICs did not increase. Inducible clindamycin resistance declined significantly. Considerably different proportions of isolates with vancomycin MIC = 2 micro g/mL were identified by different laboratory methodologies, suggesting the need for caution in their interpretation and in comparing published data....
Substantial Morbidity for Hospitalized Children With Community-Acquired Rotavirus Infections: 2005-2007 IMPACT Surveillance in Canadian Hospitals - The Pediatric Infectious Disease Journal
Le Saux N et al. – The authors describe community–acquired rotavirus illness in 1359 children hospitalized at 12 centers in Canada between January 2005 and December 2007. The median age was 1.5 years. Almost half (48.6%) had significant dehydration, almost one–fifth (19%) had clinical sepsis and 7% had seizures at presentation. The median hospital stay was 3.4 days. Severe clinical presentations are less commonly described in surveillance programs....
Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa - BMC Complementary and Alternative Medicine
Sherlock O et al. – Due to its high antimicrobial activity, Ulmo 90 may warrant further investigation as a possible alternative therapy for wound healing....
HIV protease inhibitors and obesity - Current Opinion in Endocrinology, Diabetes and Obesity
Anuurad E et al. – To review the current scientific literature and recent clinical trials on HIV protease inhibitors and their potential role in the pathogenesis of lipodystrophy and metabolic disorders. Protease inhibitors are a key component of antiretroviral therapy and have dramatically improved the life expectancy of HIV–infected individuals. However, they are also associated with abnormalities in glucose/lipid metabolism and body fat distribution. Further studies are needed to better define the pathogenesis of protease inhibitor–associated metabolic and body fat changes and their potential treatment....
Sepsis-associated electroencephalographic changes in extremely low gestational age neonates - Early Human Development
Helderman JB et al. – Sepsis is associated with acute electroencephalographic changes, as indicated by burst supression, but not with a decreased rate of brain wave maturation....
Complications of Varicella After Implementation of Routine Childhood Varicella Vaccination in Germany - The Pediatric Infectious Disease Journal
Spackova M et al. – A country–wide sentinel surveillance system was initiated in Germany after implementation of routine varicella vaccination of children >11 months. Sentinel physicians report monthly the number of cases and of severe varicella complications (VC). Case–based questionnaires are completed for VC. The authors evaluated trend and clinical features of reported VC from April 2005 to March 2009. ...

September 02, 2010
Difficulties in the Treatment of Intestinal Amoebiasis in Mentally Disabled Individuals at a Rehabilitation Institution for the Intellectually Impaired in Japan - Chemotherapy
Fujishima T et al. – A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. Combination therapy successfully cured and prevented transmission of the mass E. histolytica infection at the institution....
Education, survival and avoidable deaths in cancer patients in Finland - British Journal of Cancer
Pokhrel A et al. – Relative survival after cancer in Finland is at the highest level observed in Europe and has, in general, been on a steady increase. The study assesses whether the high survival is equally shared by different population subgroups and to estimate the possible gains that might be achieved if equity prevailed....
Evaluation of Anti-Quorum-Sensing Activity of Edible Plants and Fruits through Inhibition of the N-Acyl-Homoserine Lactone System in Chromobacterium violaceum and Pseudomonas aeruginosa - Chemotherapy
Musthafa KS et al. – The study describes the quorum–sensing (QS) inhibitory activity of edible plants and fruits against N–acyl–homoserine lactone (AHL)–mediated violacein production in Chromobacterium violaceum and virulence factor expression in Pseudomonas aeruginosa PAO1. The study identified the anti–QS activity of A. comosus, M. paradiciaca, M. zapota and O. sanctum. An AHL–inactivating compound from these plant sources can be used as an alternative to antibiotic compounds to prevent AHL–mediated bacterial infection in higher organisms....
Antivirals for Influenza: Strategies for Use in Pediatrics - Pediatric Drugs
Smith SM et al. – Additional concerns with neuraminidase inhibitor use in pediatrics center around emerging reports, primarily from Japan, that have temporally linked oseltamivir to significant neuropsychiatric events in children of varying ages. Numerous novel antiviral agents are under development, but most are far from market approval. In addition to treating and preventing the initial burden of pediatric influenza infection, antiviral therapies may significantly reduce secondary bacterial infections, unnecessary antibiotic prescribing, and healthcare–associated costs....

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