September 02, 2010
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| Early Medical and Behavioral Characteristics of NICU Infants Later Classified With ASD - Pediatrics |
| Karmel BZ et al. – Differences in specific behavior domains between NICU graduates who later receive a diagnosis of (Autism spectrum disorder)ASD and matched NICU control children may be identified in early infancy. Studies with this cohort may provide insights to help understand and detect early disabilities, including (Autism spectrum disorder) ASD.... |
August 30, 2010
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| Optimizing Antibiotic Use in the Intensive Care Unit - Clinical Pulmonary Medicine |
| Ulldemolins M et al. – Optimizing antibiotic therapy involves early initiation of appropriate antibiotics, de–escalation where appropriate, minimization of duration of therapy, and avoidance of drug interactions. Furthermore, current opinion suggests that there remains significant capacity for improved antibiotic dosing in the ICU. Application of knowledge of the effect of pathophysiology on drug pharmacokinetics and dose adjustments that adhere to pharmacodynamic principles will facilitate improved antibiotic dosing in these “at risk” ICU patients.... |
| Tracheal Bronchus: A Cause of Unexplained Prolonged Hypoxemia During Ventilation - Pediatric Cardiology |
| Srivastava A et al. – The spectrum of disorders involving the tracheobronchial tree is diverse, with some of the conditions unique to the pediatric population. Despite the "airway first" maxim, many such disorders are missed initially. Tracheal bronchus is one such condition that comes to notice by persistent right upper lobe atelectasis, pneumothorax, recurrent pneumonia, chronic bronchitis, and prolonged ventilation. This anatomic variant in a patient with cyanotic congenital heart disease is reported. For this patient, timely identification of tracheal bronchus allowed appropriate changes in airway management and was life saving.... |
August 27, 2010
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| Risk Factors for Catheter-associated Bloodstream Infections in a Pediatric Cardiac Intensive Care Unit - The Pediatric Infectious Disease Journal |
| Prasad PA et al. – In this study population, tunneled catheters were associated with a higher risk of CA–BSI, possibly because of the catheter material. Additionally, authors did not find that the burden of catheters and medical devices was associated with an increased risk of infection. Because most CA–BSIs in this study population occurred >=7 days after catheter insertion, strict attention to aseptic technique when using or dressing a catheter might reduce CA–BSI rates in the pediatric CICU.... |
| PIRO Concepts in Respiratory Sepsis - Clinical Pulmonary Medicine |
| Moreno RP – In this manuscript, the authors propose the use of a modified version of the PIRO system (based on predisposition, infection, response, and organ dysfunction/failure) to stratify patients admitted to the intensive care unit (ICU) with severe infection and sepsis. The proposed model, presented excellent calibration and discrimination in the global population and in specific groups of patients and seems to be able to replace the use of several disease–specific models. It allows the user to stratify patients based on severity and to forecast vital status at hospital discharge based on a small set of variables, collected at ICU admission or in the first 48 hours in the ICU.... |
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